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News 1210 views last update:Feb 25, 2016

Consortium completes exome sequence in pigs

PIC, a division of Genus, in cooperation with Edinburgh Genomics and the University of Edinburgh’s Roslin Institute UK, have completed exome sequencing in pigs.

Exome sequencing is a cost-effective strategy to selectively sequence the most important parts of DNA and enables faster genomic progress. According to the consortium they are the first to complete an exome sequence in pigs.

Exome sequencing has been used in humans to aid in the diagnosis of Mendelian disorders (genetic disorders associated with the mutation of a single gene). PIC will use the information derived from this research, which also received funding from the Roslin Foundation and the Biotechnology and Biological Sciences Research Council (BBSRC), to achieve more accurate genomic selection in swine, including work to reduce embryonic and/ or foetal death loss in gestating pigs.

The results of this research were published in the journal BMC Genomics in July 2014. They were generated from a targeted set of 96 pigs representing the known variation in one of PIC's proprietary populations in order to capture as many mutations as possible.

Prof David Hume, director of the Roslin Institute and a co-author of the study said: "The development of a novel genomic platform is a significant output from the long term strategic partnership between The Roslin Institute and Genus. Within the Institute, we see many applications of this platform in biomedical research as well as more applied applications in animal breeding."

Dr Jonathan Lightner, Genus chief scientific officer, congratulated Edinburgh Genomics for the study achieving coverage statistics similar to those seen with commercially available human exome kits. He added, "PIC will continue to invest in and partner with leading global institutions to develop the next generation of technologies that drive faster genomic progress."

A link to the research paper can be found here.

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