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Products to reduce pain, fever and inflammation in swine

Aurora Pharmaceutical introduces two new products for livestock producers, ORAL-PRO Sodium Salicylate 48.6% and ORAL-PRO Sodium Salicylate 60% with 5.7% caffeine. Both products are labeled for use in drinking water of poultry and swine as an aid in reducing pain, fever and inflammation.

Due to the lack of anti-viral drugs approved for use in food animals, sodium salicylate and aspirin have been an inexpensive treatment for food-producing animals and also is readily available from OTC outlets (2). Current vaccine protocols to prevent porcine reproductive and respiratory syndrome and swine influenza have not controlled the viral diseases and producers are turning to sodium salicylate and aspirin products to offset the performance losses associated with pyrexia and anorexia(2).
Aspirin compared to sodium Salicylate:
1.      Unlike liquid aspirin, sodium salicylate is highly dissoluble in water with one gram dissolving in slightly less than 1ml and aspirin is as much as 300 times less soluble, with one gram of aspirin dissolving in 300 ml of water (1).
2.      Unlike liquid aspirin, sodium salicylate administered orally through a water –medication system is absorbed and reaches measurable plasma concentrations (2).
3.       Finally, unlike aspirin, sodium salicylate does not interfere with normal blood clotting and wound healing (3).
4.      Research has shown that liquid aspirin’s highest achievable dose in swine would be 3.1 mg per kg per day and is unable to deliver the recommended dose of 48 mg per kg per day when administered in drinking water (4).
Aurora Pharmaceutical is a FDA inspected facility and manufactures under cGMP standards. All raw materials are USP grade and tested for potency and impurities. Aurora products are required to pass stability testing prior to release for sale thus, guaranteeing consistency.
1.        Budavari, S., M.J. O’Neil, A. Smith, and P.E. Heckelman, 1989. The Merck index, 11th ed. Merck & Co. Rahway, NJ.
2.        Patterson AR, Karriker LA, Apley MD, et al. Plasma concentrations of sodium Salicylate in nursery pigs treated orally. J Swine Health Prod. 2007; 15(3): 146-151.
3.        Osol, A., R. Pratt, and A.R. Gennaro, 1973 p. 162. The United States Dispensatory, 27th ed. J.B. Lippincott Co. Philadelphia, PA.
4.        Langston C, Apley MD, Boothe DM, Clark TP, Davidson GF, Dowling P, Kemp DT, Papich MG, Riddell MG, Riviere JE, Tubbs RC, Wilcke JR, USP Veterinary Pharmaceutical Information Monographs – Anti-inflammatories. J Vet Pharmacol Ther. 2004;27 (S1):4-14.

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