Medication via liquid feeds – do we need further controls? 10 Nov 2008
Author: David Burch
In the UK, our Veterinary Medicines Directorate are
planning to restrict the use of medicines – medicated feed premixes and water
soluble products - in liquid feeds. These medicines will not be allowed to be
added to liquid feeds directly. What is the situation in the rest of Europe, how
do you medicate liquid feeds?
In the UK, our Veterinary Medicines Directorate (VMD) are planning to
restrict the use of medicines – medicated feed premixes (MFPs) and water soluble
products (WSPs) - in liquid feeds. These medicines will not be allowed to be
added to liquid feeds directly. What is the situation in the rest of Europe, how
do you medicate liquid feeds?
We have been fortunate in the UK to be
allowed to medicate feed on farm, as well as via the feed mill and there are a
set of regulations and guidelines, which have to be followed. Importantly, farms
can be licensed to add prescription-only medicines (POM) such as antimicrobial
MFPs and are inspected, to check they comply.
Liquid feeding of pigs has
always been an important method of rearing pigs, especially in finishers and
also in sows. Approximately, 30% of finishing pigs here are on liquid feed and
it is a useful method of disposing of nutritious by-products from the dairy and
the brewing industries. Many other countries have much higher percentages of
pigs on liquid feed (e.g. Ireland, Denmark) since the introduction of
Salmonella monitoring and control. It is a useful way of reducing the
incidence, especially, if the feed is fermented or acidified to bring the pH
down.
The future plan is that MFPs can be only added to dry feed in the
normal way and water soluble products can be added to water, in both cases prior
to mixing and distribution to pens in the normal way. For pulse feeding where
the mixing with water is in small and regular quantities this is fine. However,
when there is a large mixing tank, which is strongly agitated and then the
contents are thoroughly mixed and pumped out to the troughs, is there really any
need to restrict the addition of the premix or a pre-dissolved soluble
formulation directly into the tank?
The consultation document states that
it is ‘To ensure that the correct amount of medicine is consumed and that the
risks of over-dosing, proliferation of antimicrobial resistance or poor health
through under-dosing are minimised.’
In my experience, feed premixes and
water solubles have been successfully added to liquid feeds for over 30 years
and generally have been a very effective way of administering treatment to
finishing pigs. Where there are big tanks, the quantity of medication to be
added, calculated on a mg of drug/kg bodyweight basis, gives a far more accurate
dose than in feed concentration in parts per million (ppm). Similarly, with
soluble products, the dose can be more accurately determined for the group of
pigs, where water intake can fluctuate with temperature. Those pigs that are
neither drinking nor eating will need an injection if they are going to
survive.
If we do medicate liquid feed directly with premixes or water
solubles then it is proposed to be under ‘cascade’ and a 28 day withdrawal
period should be applied. In the UK, there is only one product formally approved
for use in liquid feeds and that is for the treatment of Actinobacillus
pleuropneumoniae only. So, if there is an outbreak of dysentery or ileitis
towards the end of finishing, one could be in real trouble, as the delay may
lead to over-weight pigs.
So what is the situation in other countries?
How do you medicate liquid feed? It would be very useful to get some feedback on
this – as regulations in one country have a habit of spreading across the rest
of the EU.
The major problem encountered throughout Europe with authorisations of VMPs for liquid feeds is pharmaceutical legislation.
It is believed by some/many regulators that the get an authorisation for mixing with liquid feed, one has not only to demonstrate stability, but also bioequivalence with the alternative authorised route of medication (i.e. water/dry feed). Only recently our company got an authorisation for Solacyl (sodium salicylate), but only for water/milk medication in pigs/calves. At application we also requested an authorisatiion for liquid feed and demonstrated that the compound remains fully stable for 24 hours in liquid feed at 30C. We were subsequently requested to demonstrate full bioeuquivalence, which we refused. In the Netherlands there is an unofficial protocol for testing VMP's in liquid feed. A short article was published in the National Pig Health Services Journal(GD Varken 31. Medicaties van varkens per injectie, water of voer. September 2003, p. 10-12 article in Dutch). If one follows that protocol, one can send the results to the IKB (a pig-organisation which controls the complete pig food chain). They determine which products may be included on a list of VMPs suitable for liquid feed medication. So these products are not officially authorised, yet they are approved. Just Google for IKB/positive list/pig and you will find some hits. From there on you may find contact points for further information
Kind regards
Peter Verhoeve
DVM Eurovet AH