Enzo Otic pneumonia is caused by infection with Mycoplasma hyopneumoniae, a small, less shape, delicate bacterium, which is difficult to grow in culture in the laboratory. The cell surface bears fimbriae (filaments) but there is no cell wall (present in most bacteria), and M. hyopneumoniae is therefore sensitive to drying and is generally resistant to penicillin. A number of strains exist, but all appear to produce a similar lactate dehydrogenase enzyme and to react in a similar, but not exactly the same, way to antisera, and all can be distinguished from related mycoplasmas.
The organism grows on the cells lining the trachea, bronchi and bronchioles (rigid airways of the lung) or non-immune pigs, attaching to the cilia (hairs Actively beating), paralysis them, causing their loss and results in the accumulation of respiratory tract secretions in the lowest parts of the lung and in pneumonia.
It is found in the blood, but does not cross the placenta. Inflammatory cells and antibody-producing cells surround the affected airways and are common in the pneumonic lung. Immunity develops and eventually the pneumonia clears after a period of months, although antibody can be detected in the blood and the mycoplasmas persist in the airways in recovered pigs.
Few clinical signs of infection occur in chronically infected herds. Infection at 3.10 weeks of age after 10-16 days is followed by transient diarrhea and a dry cough. A low fever may occur. A barking cough is common in finishing pigs, particularly when the animals are disturbed. Gradually coughing spreads to most members of the group within 3-14 weeks and lasts for about 50 days.
Animals gradually develop uneven size. Growth rate from 5-85 kg may be depressed by up to 15.9% and feed conversion ratios increase by up to 13.8%. Dust, chilling, high humidity and high ammonia levels exacerbate these effects on growth which appear to be proportional to the volume of lung affected.
Severe pneumonia and coughing occur in pigs 2-4 months old (and at 18-20 weeks of age in the U.S.) when other infections are present. In SPF herd breakdowns, pigs of all ages may be affected by inappetence, fever to 41.7 ° C (105 ° F), respiratory distress and coughing. Some adults and up to 50% of the piglets, often before coughing is apparent. Boars may not work and extended weaning to service intervals will occur. Infection of some SPF herds has been inapparent.
Enzo Otic pneumonia should be suspected when coughing occurs in a herd, particularly in fattening pigs, associated with uneven growth rate and poor feed conversion efficiency but with no mortality.
In an SPF herd, the disease should be suspected if fever, coughing, respiratory distress and mortality occur. Pneumonia is present in the lungs of affected pigs as plum-colored pink or changes in the portions which hang down in life (the dependent parts of the cranial lobes) and microscopic changes of the disease are present. These changes are still present in many herds at slaughter.
Confirmation by laboratory testing is essential for diagnosis, especially in monitoring schemes. Infection can be confirmed by the culture of M. hyopneumoniae from affected lung tissue in specialist laboratories or by its demonstration in the airways or lung using fluorescent antibody, immunoperoxidase staining, other serological tests for the organism or the Polymerase Chain Reaction (PCR) which specifically detects M hyopneumoniae DNA. Serological testing for antibody (using a commercial ELISA test) confirms the presence of past infection in an animal and the presence of the infection in a herd. The age at which infection occurs in a herd or in a building, can be determined by serum antibody testing (serum profiling).
Enzo Otic pneumonia can be treated using valnemulin, tiamulin, lincomycin, enrofloxacin, marbofloxacin and Tylosin or other macrolide antibiotics. Tetracyclines prevent the disease. Tiamulin and can eliminate valnemulin M. hyopneumoniae from animals. Lesions do not regress immediately.
Control is based on husbandry methods to reduce disease such as all-inclusive, all-out management of accommodation or sites, Isowean TM, treatment of the group on entering an airspace or use of an effective therapeutic at a low level for a period (where registered). A number of effective killed vaccines can be used to prevent disease. These are generally given at 1 and 3 weeks of age and protect from 4.5 weeks, reducing the number and extent of the lung lesions and improve growth rates and profitability.
The disease can be eradicated by depopulation followed by restocking with so otic pneumonia-free pigs. It has been eradicated from smaller farms by partial depopulation and treating breeding stock with tiamulin and valnemulin. Serological monitoring confirms freedom from infection.
Enzo Otic pneumonia-free farms must use so otic pneumonia free breeding stock, must be sited 3.2 km from any other pig farm (the organism can spread by aerosol) must maintain a barrier and Ensure that visitors have not been in recent contact with pigs.
