This period has been generally designated as the “immunity window” (1). On the other hand, our previous studies and studies of other authors (1-3) indicated that colostrum-derived antibodies do not completely prevent the immune response after immunization and that this period could be overcome or shortened by properly timed vaccination, local administration of antigens and/or by the use of proper type of adjuvant.
The aims of this study were to verify the possibility of overcoming the inhibitory effect of colostrum-derived antibodies in piglets using immunization via the skin or mucosae and to test the effect of higher proportions of adjuvant and/or higher concentrations of model antigen on quality and quantity of induced local and systemic immune responses.
Katerina Nechvatalova; Martin Faldyna; Eduard Gopfert; Pavlina Knotigova; Hana Kudlackova; Lenka Leva
Veterinary Research Institute Brno, Brno, Czech Republic
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