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Pleuromutilin susceptibility of Clostridium perfringens and Clostridium difficile isolates from pigs in Italy and Denmark

//28 Oct 2010

By Allison Winstanley

Clostridium perfringens type A is a causative agent of diarrhea in neonatal piglets with widespread occurrence in many pig producing areas; indeed the consensus β2 toxin (cpb2con) was recently considered the key virulence factor characterising the strains involved in neonatal enteritis of pigs (1, 2). The role of Clostridium difficile in neonatal diarrhea is increasing and becoming of greater clinical importance (3, 4) in many countries.

Aim of the study was to assess the MIC values of toxigenic C. perfringens and C. difficile isolates from neonatal healthy piglets (less than 7 days old) or affected by enteritis, collected in Italian and Danish farms, against the pleuromutilin antibiotics, tiamulin and valnemulin (DenagardR & EconorR respectively - Novartis Animal Health Inc.)

Fabrizio Agnoletti¹Ilenia Drigo¹ Luca Bano¹ Ulrich Klein² Josef Szancer³
1. Istituto Zooprofi lattico Sperimentale delle Venezie, Treviso, Italy; 2. Novartis Animal Health Inc., Basel, Switzerland; 3. Novartis Animal Health, Copenhagen, Denmark

For full presentation see attached pdf